Understanding Alzheimer’s Disease

Dr Aparna Vijay Kumar
September 20, 2020

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Alzheimer’s disease is a common cause of dementia. Dementia is a general term for loss of memory. Along with loss of short term memory, individuals develop loss of reasoning and thinking; as well as behaviour disturbances.

It is not just a disease of old age, though, it is often seen above 65 years of age. In less than 10% of cases, it is seen in patients between 40 to 60 years of age. It starts with difficulty in learning new things which shows impact on working memory, getting lost in familiar places followed by forgetting people, emotional and behavioural disturbances subsequently leading to a mute, bed bound state.

It is due to death of brain cells or neurons in memory area of the brain causing loss of connectivity with other neurons by the deposition of abnormal protein beta amyloid and tau. What causes this formation of protein is still under research. A combination of genetic, environmental and lifestyle factors is implicated.

The presence of apolipoprotein gene (APOE ) increases the risk but neither all individuals with the gene develop the disease nor all individuals with Alzheimer’s disease have this gene. Presence of metabolic conditions like diabetes, hypertension, heart disease, obesity, obstructive sleep apnea; diet and level of physical and mental activity also are implicated.

Diagnosis is only by clinical history and neurological examination. Imaging like SPECT, PET and MRI brain help in confirmation and ruling out treatable causes of dementia.

It is a slowly progressive disease with no cure as brain cells do not regenerate. Treatment with drugs aims at controlling the symptoms and slowing the progression by regulating the level of neurotransmitters or chemicals.

Care givers have a very challenging and important role in management of patients as caring of a person with Alzheimer’s disease causes physical and financial burden. Care givers also need support to cope up with the stress of handling their loved ones.

The take home message is that a healthy diet and regular exercise early on in life reduces the risk of Alzheimer’s disease. Healthy diet and regular exercise also prevent life style diseases like diabetes, hypertension, obesity and heart problems. Regular walking increases the level of a chemical brain derived neurotrophic factor( BNF) which potentiates memory.

A Mediterranean style of diet rich in fresh fruits and vegetables, nuts, legumes, olive oil has been shown to prevent the progression of disease in patients with minimal cognitive decline, a precursor of Alzheimer’s disease. Diet rich in curcumin, omega-3 fatty acids and cocoa have proven benefits with vitamin B12,D, E  and folate supplements.

 

Dr Aparna Vijay Kumar Senior Neurologist, Citizens Specialty Hospital

Comments

S C Sharma
 - 
Tuesday, 22 Sep 2020

Very informative article explaining in simplest language.

rmangala raman
 - 
Monday, 21 Sep 2020

Highly informative beneficial and clearly simplified to reach common man. Thank you.

S.Bhagyam Sharma
 - 
Monday, 21 Sep 2020

Very good information thank you very much Dr Aparna

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News Network
November 24,2025

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Israeli forces have pushed over the Syrian frontier, erecting a checkpoint and stopping vehicles in the southwestern city of Quneitra, in yet another breach of the Arab country’s sovereignty.

The violation took place on Sunday, when the troops made their way across the border, setting up the outpost near the Ain al-Bayda junction in northern Quneitra, Syrian outlets reported.

According to the al-Ikhbariya paper, an Israeli detachment positioned itself at the junction, halting cars and conducting searches.

The Syrian Arab News Agency (SANA) reported that three Israeli military vehicles then moved further into the northern countryside, deploying between the town of Jubata al-Khashab and the villages of Ofaniya and Ain al-Bayda. The agency added that a separate Israeli unit mounted a new incursion in the central region, approaching the villages of Umm Batina and al-Ajraf.

Residents said such activities have surged in recent months, pointing to Israeli advances onto farmland, leveling of extensive forested areas, arrests, and spread of mobile checkpoints.

The Israeli regime began markedly increasing its military aggression against Syria last year.

The escalation coincided with increasingly ferocious onslaughts throughout the country by the so-called Hay'at Tahrir al-Sham (HTS) Takfiri terrorist group, which the government of President Bashar al-Assad had confined to northwestern Syria. The HTS, however, managed to overthrow the government as the Israeli attacks would pummel the country’s civilian and defensive infrastructure.

Various reports have shown that, during the escalation, the regime conducted more than 1,000 airstrikes on the Syrian territory and over 400 ground raids into the south.

Following the collapse of the Assad government, Tel Aviv also widened its grip over the occupied Golan Heights by taking control of a demilitarized buffer zone, in defiance of a 1974 Disengagement Agreement. Earlier this month, senior Israeli officials, including Prime Minister Benjamin Netanyahu, visited the buffer zone, prompting expressions of alarm on the part of the United Nations.

The United States, the regime’s biggest ally, has, meanwhile, been fraternizing the HTS head Abu Mohammed al-Jolani amid the widely reported prospect of rapprochement with Tel Aviv.

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News Network
November 29,2025

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New Delhi: Karnataka chief minister Siddaramaiah and deputy CM DK Shivakumar on Saturday put up a dramatic display of unity at a closely watched joint press briefing, firmly dismissing weeks of speculation about a power-sharing tussle within the Congress. With the high command nudging both leaders to sit together and settle the dust, the meeting became a political spectacle, ending with the duo declaring that there was “no confusion, no differences.”

Calling the reports of a rift “manufactured confusion,” Siddaramaiah said the talks had gone smoothly, even joking about their breakfast. “Breakfast was very good. All three of us enjoyed it,” he said. “We want to end this confusion once and for all. For local elections and for 2028, our mission is clear — Congress must return to power. There is no difference between me and DKS, not now, not before.”

He blamed the media for fuelling rumours and reiterated absolute adherence to the party leadership. “From tomorrow, let there be no confusion. What the high command says, we will follow.”

Siddaramaiah also assured that the Assembly session starting December 8 would run smoothly and vowed that Congress would take on the BJP and JD(S) “together.”

Shivakumar echoed the chief minister word for word, stressing loyalty and discipline. “People have given us a massive mandate. It is our duty to deliver,” he said. “This government was formed under Siddaramaiah’s leadership. We both have complete trust in the high command. If they tell me to wait, I will wait.”

He added that the two leaders had discussed strategy for the 2028 Assembly elections. “Whatever the CM says, I agree. We are loyal soldiers of the party. The party may be facing challenges nationally, but we will keep it strong in Karnataka.”

Shivakumar also said Siddaramaiah would soon visit his home for lunch or dinner — another symbolic gesture meant to underline their unity.

Both leaders later posted on social media describing the breakfast meeting as “productive” and focused on “Karnataka’s priorities.”

The BJP, however, rejected the show of camaraderie as “pure bunkum,” accusing Congress of trying to paper over an internal power struggle. But Siddaramaiah and Shivakumar insisted their united front would continue — and that there was “no confusion” within the state leadership.

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News Network
November 27,2025

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Bengaluru: The Vokkaligara Sangha on Thursday issued a stern warning to the Congress, saying the party could face serious electoral repercussions if Deputy Chief Minister D.K. Shivakumar is not appointed as Chief Minister.

The warning follows the public backing of Shivakumar’s chief ministerial ambition by top Vokkaliga pontiff Nirmalanandanatha Swami, who urged the Congress high command to honor his claim.

“The community supported Congress in the 2023 Assembly elections only because Shivakumar had a real chance to become CM. If he is cheated, we’ll teach the party a big lesson,” said newly elected Sangha president L. Srinivas. He added that Vokkaligas would organize protests under the guidance of community leaders.

General Secretary C.G. Gangadhar pointed out that Congress won more seats in the Vokkaliga-dominated Old Mysuru region due to Shivakumar’s influence, adding, “If Congress wants to retain power, Shivakumar should be made the CM.”

Outgoing president Kenchappa Gowda emphasized Shivakumar’s contribution to Congress’ victory. “Our community voted for Congress thinking he would become CM. Siddaramaiah has also served the party well, but Shivakumar should now be given a chance,” he said.

Former general-secretary Konappa Reddy appealed to Sonia and Rahul Gandhi to recognize Shivakumar’s loyalty and service, saying, “Congress is known to keep its promises. We hope it won’t break the promise made to him.”

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