Understanding Alzheimer’s Disease

Dr Aparna Vijay Kumar
September 20, 2020

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Alzheimer’s disease is a common cause of dementia. Dementia is a general term for loss of memory. Along with loss of short term memory, individuals develop loss of reasoning and thinking; as well as behaviour disturbances.

It is not just a disease of old age, though, it is often seen above 65 years of age. In less than 10% of cases, it is seen in patients between 40 to 60 years of age. It starts with difficulty in learning new things which shows impact on working memory, getting lost in familiar places followed by forgetting people, emotional and behavioural disturbances subsequently leading to a mute, bed bound state.

It is due to death of brain cells or neurons in memory area of the brain causing loss of connectivity with other neurons by the deposition of abnormal protein beta amyloid and tau. What causes this formation of protein is still under research. A combination of genetic, environmental and lifestyle factors is implicated.

The presence of apolipoprotein gene (APOE ) increases the risk but neither all individuals with the gene develop the disease nor all individuals with Alzheimer’s disease have this gene. Presence of metabolic conditions like diabetes, hypertension, heart disease, obesity, obstructive sleep apnea; diet and level of physical and mental activity also are implicated.

Diagnosis is only by clinical history and neurological examination. Imaging like SPECT, PET and MRI brain help in confirmation and ruling out treatable causes of dementia.

It is a slowly progressive disease with no cure as brain cells do not regenerate. Treatment with drugs aims at controlling the symptoms and slowing the progression by regulating the level of neurotransmitters or chemicals.

Care givers have a very challenging and important role in management of patients as caring of a person with Alzheimer’s disease causes physical and financial burden. Care givers also need support to cope up with the stress of handling their loved ones.

The take home message is that a healthy diet and regular exercise early on in life reduces the risk of Alzheimer’s disease. Healthy diet and regular exercise also prevent life style diseases like diabetes, hypertension, obesity and heart problems. Regular walking increases the level of a chemical brain derived neurotrophic factor( BNF) which potentiates memory.

A Mediterranean style of diet rich in fresh fruits and vegetables, nuts, legumes, olive oil has been shown to prevent the progression of disease in patients with minimal cognitive decline, a precursor of Alzheimer’s disease. Diet rich in curcumin, omega-3 fatty acids and cocoa have proven benefits with vitamin B12,D, E  and folate supplements.

 

Dr Aparna Vijay Kumar Senior Neurologist, Citizens Specialty Hospital

Comments

S C Sharma
 - 
Tuesday, 22 Sep 2020

Very informative article explaining in simplest language.

rmangala raman
 - 
Monday, 21 Sep 2020

Highly informative beneficial and clearly simplified to reach common man. Thank you.

S.Bhagyam Sharma
 - 
Monday, 21 Sep 2020

Very good information thank you very much Dr Aparna

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News Network
November 29,2025

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New Delhi: Karnataka chief minister Siddaramaiah and deputy CM DK Shivakumar on Saturday put up a dramatic display of unity at a closely watched joint press briefing, firmly dismissing weeks of speculation about a power-sharing tussle within the Congress. With the high command nudging both leaders to sit together and settle the dust, the meeting became a political spectacle, ending with the duo declaring that there was “no confusion, no differences.”

Calling the reports of a rift “manufactured confusion,” Siddaramaiah said the talks had gone smoothly, even joking about their breakfast. “Breakfast was very good. All three of us enjoyed it,” he said. “We want to end this confusion once and for all. For local elections and for 2028, our mission is clear — Congress must return to power. There is no difference between me and DKS, not now, not before.”

He blamed the media for fuelling rumours and reiterated absolute adherence to the party leadership. “From tomorrow, let there be no confusion. What the high command says, we will follow.”

Siddaramaiah also assured that the Assembly session starting December 8 would run smoothly and vowed that Congress would take on the BJP and JD(S) “together.”

Shivakumar echoed the chief minister word for word, stressing loyalty and discipline. “People have given us a massive mandate. It is our duty to deliver,” he said. “This government was formed under Siddaramaiah’s leadership. We both have complete trust in the high command. If they tell me to wait, I will wait.”

He added that the two leaders had discussed strategy for the 2028 Assembly elections. “Whatever the CM says, I agree. We are loyal soldiers of the party. The party may be facing challenges nationally, but we will keep it strong in Karnataka.”

Shivakumar also said Siddaramaiah would soon visit his home for lunch or dinner — another symbolic gesture meant to underline their unity.

Both leaders later posted on social media describing the breakfast meeting as “productive” and focused on “Karnataka’s priorities.”

The BJP, however, rejected the show of camaraderie as “pure bunkum,” accusing Congress of trying to paper over an internal power struggle. But Siddaramaiah and Shivakumar insisted their united front would continue — and that there was “no confusion” within the state leadership.

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News Network
December 1,2025

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Udupi, Dec 1: A horrific case of alleged rape has unfolded in Udupi, where a worker from a Hindutva organisation, previously arrested and released on bail for harassing a young woman, is now accused of waylaying and sexually assaulting her.

The arrested individual has been identified as Pradeep Poojary (26), a member of the Hindu Jagarana Vedike's Nairkode unit in Perdur.

Poojary had allegedly been relentlessly harassing the young woman, pressuring her to marry him. When she bravely stood up to him and refused his demands, she filed a formal complaint at the Hiriyadka police station. He was subsequently arrested in that initial harassment case but was later granted bail.

According to police reports, driven by the same malicious grudge, Poojary allegedly intercepted the woman again on November 29. While she was walking through a deserted area, the accused is claimed to have threatened her by grabbing her neck. When she again refused to marry him, he allegedly proceeded to rape her.

The survivor immediately informed her family about the traumatic assault. Following this, her parents lodged a complaint at the Udupi women’s police station.

Police arrested Poojary again and produced him before the court. He has since been remanded to judicial custody.

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News Network
November 26,2025

Mangaluru, Nov 26: Assembly Speaker and local MLA U.T. Khader has initiated a high-level push to resolve one of Mangaluru’s longest-standing traffic headaches: the narrow, high-density stretch of National Highway-66 between Nanthoor and Talapady.

He announced on Tuesday that a formal proposal has been submitted to the Union Ministry of Road Transport and Highways (MoRTH) seeking approval to prepare a Detailed Project Report (DPR) for the widening of this crucial corridor.

The plan specifically aims to expand the existing 45-meter road width to a full 60 meters, coupled with the construction of dedicated service roads. Khader highlighted that land for a 60-meter highway was originally acquired during the initial four-laning project, but only 45 meters were developed, leading to a perpetual bottleneck.

"With vehicle density rising sharply, the expansion has become unavoidable," Khader stated, stressing that the upgrade is essential for ensuring smoother traffic flow and improving safety at the city's main entry and exit points.

The stretch between Nanthoor and Talapady is a vital link on the busy Kochi-Panvel coastal highway and connects to major city junctions. The move to utilize the previously acquired land for the full 60-meter width is seen as a necessary measure to catch up with the region's rapid vehicular growth and prevent further traffic gridlocks.

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