Tamarind seed protein has potential to cure Chikungunya: IIT-R study

Agencies
November 14, 2018

New Delhi, Nov 14: Two professors at Indian Institute of Technology (IIT) Roorkee claimed to have discovered a protein in tamarind seeds that has anti-viral properties and can potentially be used to develop medication for chikungunya.

The research group at IIT Roorkee has filed a patent for an antiviral composition containing this tamarind antiviral protein and is now developing tamarind-based therapeutic agents for chikungunya.

"Tamarind is known for various medicinal properties in India and is a excellent Ayurvedic food. The fruits, seeds, leaves and roots bark of the tamarind tree have been used to treat abdominal pain, diarrhoea and dysentery, bacterial infections and parasitic infestations, wounds, constipation and inflammation," said one of the professors, Shaily Tomar.

Lectin, a diverse group of proteins derived from plant sources, are known to bind to glycan sugars. Its use as antiviral has been extensively studied for a range of viruses, including HIV and HPV.

The IIT professors, in a study, have shown that a lectin derived from tamarind seeds bind to glycans or sugar molecules having N-acetylglucosamine (NAG) on the capsule of viruses, thereby preventing the entry of the virus into the host cells.

The researchers have isolated lectin from tamarind seeds using chromatography and have studied the binding of the lectin molecules to the glycan in the viral capsule by a process called Enzyme-Linked ImmunoSorbent Assay (ELISA).

"Not only did the chikungunya virus lose 64 per cent of its infectivity on treatment with the lectin, but the levels of viral RNA in the cells were also found to reduce to nearly 45 per cent. This study has, for the first time, evaluated the antiviral use of tamarind seed-derived lectin having specificity for NAG and assessed its ability to block the entry step of the virus," Tomar added.

"Antiviral drugs and vaccines against most alphaviruses, including chikungunya are still not available in the market, and preventive measures are currently the only route to managing diseases caused by such viruses," said professor Pravindra Kumar, who is also part of the research.

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News Network
May 3,2024

Mangaluru, May 3: The Mangaluru City Corporation will resort to water rationing from May 5 as the Thumbe vented dam, which supplies drinking water to the city, is facing a shortage in water storage.

Instead of daily supply, water will be supplied on alternate days, the Executive Engineer (Water Supply) at the corporation said in a release.

The release said that water will be supplied to Mangaluru City North on May 5. There will be no water supply to Mangaluru City North on May 6. Instead water will be supplied to Mangaluru City South on May 6. Likewise the supply on alternate days will continue.

The inflow in the Netravathi has stopped, the release said, requesting people to cooperate with the corporation and not waste water for washing vehicles and other purposes.

An engineer at the corporation said that water level at the dam stood at 4.27 m on Wednesday against the full storage level of 6 m. If water is supplied daily to the entire city (Mangaluru City North and Mangaluru City South) the existing storage will last only for 16 days, the engineer said. Hence the decision to supply water on alternate days has been taken to supply water till May-end.

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News Network
May 5,2024

Karwar, May 5: What commenced as a mere exchange of words between spouses swiftly transmuted into a calamitous ordeal, resulting in the heartbreaking loss of their innocent offspring. The heart-wrenching incident unfolded in the serene confines of Halamaddy village in the picturesque expanse of Dandeli, nestled within the idyllic expanse of Uttara Kannada district.

In the throes of a fervent dispute with her spouse, the aggrieved wife, succumbing to an overwhelming surge of emotions, callously propelled their tender six-year-old progeny into the somber depths of a nearby canal, thereafter alerting the local populace to her grievous act.

Promptly apprised of the distressing occurrence by concerned bystanders, the authorities were swiftly summoned to the scene to confront the harrowing aftermath.

Responding to the distress call, the diligent officers of Dandeli rural police swiftly converged upon the site where the innocent child had been cast into the unforgiving waters of the canal, subsequently effecting the retrieval of the child's lifeless form. 

Regrettably, it was discerned that a portion of the child's remains had been tragically claimed by the lurking jaws of a predatory crocodile.

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News Network
April 26,2024

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Mangaluru/Udupi: The Dakshina Kannada and Udupi-Chikmagalur Lok Sabha constituencies recorded a tentative voter turnout of 77.4% and 76.1% respectively until 6 pm on Friday. In the 2019 polls, Dakshina Kannada recorded 77.9%, while Udupi recorded a 75.8% voter turnout.

The DK Lok Sabha constituency recorded a poll percentage of 71.8% at 5 pm. Among the constituencies, Sullia recorded a maximum of 78.4%, followed by Belthangady at 75.6%, Puttur at 75.2%, Bantwal at 73.7%, Mangalore at 73.5%, Mangalore City North at 69.8%, and Mangalore City South at 61.8%.

Urban apathy continued, with Mangalore City South recording the lowest polling percentage.

Meanwhile, Banjarumale, a remote village in Belthangady taluk, recorded 100% polling with all 111 voters showing up two hours before polling ended at 6pm.

Another interior polling station at Elaneer in the same taluk recorded 82% polling at 4 pm. The booth has 471 voters. The district has a total of 18,18,127 voters, with 9,30,928 females, 8,87,122 men, and 77 transgender individuals.

A good number of people turned out to vote during the early hours. Voters are bearing the scorching sun while stepping out to exercise their franchise as heat wave is sweeping through the state. 

The polling process remained largely peaceful, with long queues observed at polling stations from 7 am onwards in several polling stations. However, technical glitches caused delays at a polling station in Karopady, and at St. Xavier School Bejai, where polling was reportedly delayed by nearly two hours.

Polling staff at a booth near the Mulki police station mistakenly marked the wrong finger with ink during voting. They reportedly applied ink to the index finger of the right hand. According to sources, at least 50 individuals had their index finger of the right hand inked. Deputy Commissioner Mullai Mulihan clarified, "The matter was promptly addressed by the sector office. This error affected 8-9 voters"

A total of 18.18 lakh voters in the Dakshina Kannada Lok Sabha constituency and 15.85 lakh in Udupi-Chikmagalur hold the power to determine the fate of candidates competing for their respective segments. The polling process is currently underway across 1,876 booths in Dakshina Kannada and 1,842 polling stations in the Udupi-Chikmagalur segment.

In Dakshina Kannada, a closely contested battle is anticipated between Captain Brijesh Chowta representing the BJP and Padmaraj R Poojary from the Congress. Meanwhile, in the Udupi-Chikmagalur constituency, Kota Shrinivas Poojary of the BJP and K Jayaprakash Hegde of the Congress are the prominent contenders.

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