Understanding Alzheimer’s Disease

Dr Aparna Vijay Kumar
September 20, 2020

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Alzheimer’s disease is a common cause of dementia. Dementia is a general term for loss of memory. Along with loss of short term memory, individuals develop loss of reasoning and thinking; as well as behaviour disturbances.

It is not just a disease of old age, though, it is often seen above 65 years of age. In less than 10% of cases, it is seen in patients between 40 to 60 years of age. It starts with difficulty in learning new things which shows impact on working memory, getting lost in familiar places followed by forgetting people, emotional and behavioural disturbances subsequently leading to a mute, bed bound state.

It is due to death of brain cells or neurons in memory area of the brain causing loss of connectivity with other neurons by the deposition of abnormal protein beta amyloid and tau. What causes this formation of protein is still under research. A combination of genetic, environmental and lifestyle factors is implicated.

The presence of apolipoprotein gene (APOE ) increases the risk but neither all individuals with the gene develop the disease nor all individuals with Alzheimer’s disease have this gene. Presence of metabolic conditions like diabetes, hypertension, heart disease, obesity, obstructive sleep apnea; diet and level of physical and mental activity also are implicated.

Diagnosis is only by clinical history and neurological examination. Imaging like SPECT, PET and MRI brain help in confirmation and ruling out treatable causes of dementia.

It is a slowly progressive disease with no cure as brain cells do not regenerate. Treatment with drugs aims at controlling the symptoms and slowing the progression by regulating the level of neurotransmitters or chemicals.

Care givers have a very challenging and important role in management of patients as caring of a person with Alzheimer’s disease causes physical and financial burden. Care givers also need support to cope up with the stress of handling their loved ones.

The take home message is that a healthy diet and regular exercise early on in life reduces the risk of Alzheimer’s disease. Healthy diet and regular exercise also prevent life style diseases like diabetes, hypertension, obesity and heart problems. Regular walking increases the level of a chemical brain derived neurotrophic factor( BNF) which potentiates memory.

A Mediterranean style of diet rich in fresh fruits and vegetables, nuts, legumes, olive oil has been shown to prevent the progression of disease in patients with minimal cognitive decline, a precursor of Alzheimer’s disease. Diet rich in curcumin, omega-3 fatty acids and cocoa have proven benefits with vitamin B12,D, E  and folate supplements.

 

Dr Aparna Vijay Kumar Senior Neurologist, Citizens Specialty Hospital

Comments

S C Sharma
 - 
Tuesday, 22 Sep 2020

Very informative article explaining in simplest language.

rmangala raman
 - 
Monday, 21 Sep 2020

Highly informative beneficial and clearly simplified to reach common man. Thank you.

S.Bhagyam Sharma
 - 
Monday, 21 Sep 2020

Very good information thank you very much Dr Aparna

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News Network
April 30,2024

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Itamar Ben Gvir, a notorious far-right Israeli minister, has suggested that some Palestinians could be “killed” instead of being kidnapped during the savage war in Gaza.
 
The minister made remarks during an Israeli war cabinet meeting where he questioned the necessity of the detention of a large number of Palestinians.

“Why are there so many arrests? “Can’t you kill some? Do you want to tell me they all surrender? What are we to do with so many arrested? It’s dangerous for the soldiers.” Ben-Gvir was quoted as asking the Israeli military's chief of staff Herzi Halevi.

The minister also reportedly demanded that the army shoot Palestinian women and children in the besieged Palestinian territory to “protect” the Israeli forces.

Halevi briefed ministers who attended the cabinet meeting on the military campaign in Gaza and highlighted that hundreds of Palestinians had surrendered to the occupying forces.

Ben Gvir recently also called for the execution of Palestinian prisoners to ease overcrowding in the jails. The minister said that applying the death penalty to Palestinian detainees was the “right” solution to tackle the problem of prison overcrowding.

Israel soldiers have abducted more than 5,000 of Palestinians during their ongoing military campaign in Gaza.

The Gaza media office has said that Palestinian prisoners were undergoing "the worst kinds of torture" in Israeli jails.

Palestinian rights group Addameer earlier this month said Israel was holding 9,500 Palestinian political prisoners, not including those taken from the Gaza Strip.

Israel has arrested thousands of Palestinians since 7 October. Those detained, often without charge, describe regular beatings and a solitary daily meal designed simply to keep them alive.

Palestinians taken prisoner or hostage from both the West Bank and Gaza have given testimonies detailing horrific and sadistic abuse and torture by their Israeli jailers including beatings, verbal abuse, sexual abuse and rape, breaking of limbs, burns, being stripped naked, and forced drug taking.

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News Network
May 6,2024

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Several women, believed to be victims of Prajwal Revanna, have left their homes in Karnataka's Hassan district over the last ten days, according to media reports.

These departures reportedly come amid fear and stigma after their identities became public due to the circulating video clips showing the women who were allegedly sexually assaulted by Prajwal Revanna.

"The entire district is in H D Revanna’s control. You speak ill about them and chances are high that it will reach them, because the family and the party have a large following," a shopkeeper in Hagare - 20 km from Hassan – was quoted as saying by the news paper. 

Hassan is the bastion of the JD(S) supremo Deve Gowda, and Prajwal, his grandson, is the sitting MP.

The family of the woman whose complaint was the basis of the first FIR against Prajwal has now left their home, the publication reported, citing a neighbour who said, "The woman worked at Revanna’s house as a house help. Some of her videos started to circulate and then, her house was seen locked. We don’t know when she left."

Notably, a former Zilla Panchayat member has also filed a rape case against Prajwal, and in that village many women who worked for the party formerly are now incommunicado, a JD(S) leader told the publication. "We noticed many of the party women deleting their photos with Prajwal on social media. In some instances, men are questioning their wives about their association with the MP. It is shattering the lives of many women in the district," he said.

The local leader added that the former Zilla Panchayat member was there on April 24, but no one had seen the family since the videos came out.

The case is currently being probed by an SIT team and when they reached the Revanna residence, party workers were reportedly heard talking about the women. "I know this woman, she lived close to our residence and was very active in JD(S) activities. Her house is locked… she has small children," one said, as per IE.

Another shopkeeper added, "It was really wrong to reveal the faces of the women. I know some of them, and they have gone into hiding. We don’t know whether they can return."

He noted that it is impossible to survive in Hassan while fighting a case against the Revanna family.

While Prajwal's father, H D Revanna is in SIT custody, a Blue Corner notice has been issued against the sitting MP.

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News Network
April 26,2024

A 91-year-old woman passed away minutes after casting her vote in Karnataka's Hunsur on Friday, April 26. Hunsur comes under Mysuru Lok Sabha constituency. Despite her advanced age, Puttamma exercised her democratic right.

Voting held on Friday in 14 constituencies in Karnataka. Polling began at 7 am and will ended at 6 pm.

Chende artiste Manohar dies 

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Chende artiste Manohar (58) died of cardiac arrest after exercising his franchise in Kodagu district.

He had cast his vote at B Shettigeri polling station in Ponnampet taluk. Later, Chende artiste Manohar (58) reportedly collapsed after coming out of the polling booth. Though he was rushed to hospital, doctors declared him brought dead.

Ponnampet Tahsildar Mohankumar said “Manohar had come out of the polling booth and collapsed 200 metres away from the booth.

For the uninitiated, Chende (also known as Chenda) is a cylindrical percussion instrument widely used in cultural events in Tulu Nadu of Karnataka and Tamil Nadu in India.

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